So, Leknes and her colleagues studied how 160 patients reacted to remifentanil before undergoing minor surgery. This bias in the literature may make opioid-induced euphoria seem commonplace, Leknes said, but she wondered whether the average healthy person finds bliss while hooked to an opioid drip. Scientists are still unpacking exactly why individuals react differently to the drugs, he said.īut so far, most opioid research has been conducted with current or former addicts as participants, Leknes said, with some studies going so far as to only include participants who say they enjoy taking the drugs. "Not everyone experiences the same level of euphoria from opioids, and not everyone that uses opioids will develop an addiction or opioid use disorder," Kiluk told Live Science in an email. "However, that's not to say that addiction is solely driven by the amount of pleasure," said Brian Kiluk, a clinical psychologist and psychiatry professor at Yale School of Medicine, who was not involved with the new study. Opioid users can get hooked on this euphoric experience, develop drug cravings and dependence over time, and continue taking the drug to avoid withdrawal symptoms as their tolerance builds. Opioid drugs can relieve pain by tampering with the signals that race through this circuitry.īut cells bearing mu-receptors also link up to the brain's reward system and can spark feelings of intense pleasure, or euphoria, according to the National Institute on Drug Abuse. Mu-receptors sit within networks of cells that regulate pain in the body.
doi:10.1016/j.neubiorev.2013.11.Once administered, remifentanil flips switches in the body and brain known as mu-receptors, according to the U.S.
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